HLA disease diagnostics and pharmacogenetics
Published on 30 January 2019
Human leukocyte antigen (HLA) typing can help in the diagnosis of various disorders. GPs and hospital physicians can request a range of tests:
- HLA-B27 testing to aid the diagnosis of ankylosing spondylitis and related spondyloarthropathies
- HLA-DQB1*06:02 testing to aid the diagnosis of narcolepsy
- HLA-DQB1*02 (DQ2) and DQB1*:02 (DQ8) testing to aid the diagnosis of coeliac disease
- HLA-B*57:01 testing is performed to identify individuals who are at risk of hypersensitivity reactions to the anti-retroviral HIV drug, Abacavir
Other tests will be undertaken when referred by a recognised authority if there is clinical evidence that HLA typing could support diagnosis and patient treatment.
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