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HLA disease diagnostics and pharmacogenetics

Published on 27 August 2021

Human leukocyte antigen (HLA) typing can help in the diagnosis of various disorders. GPs and hospital physicians can request a range of tests:

  • HLA-B27 testing to aid the diagnosis of ankylosing spondylitis and related spondyloarthropathies
  • HLA-DQB1*06:02 testing to aid the diagnosis of narcolepsy
  • HLA-DQB1*02 (DQ2) and DQB1*03 (DQ8) testing to aid the diagnosis of coeliac disease
  • HLA-B*57:01 testing is performed to identify individuals who are at risk of hypersensitivity reactions to the anti-retroviral HIV drug, Abacavir

Other tests will be undertaken when referred by a recognised authority if there is clinical evidence that HLA typing could support diagnosis and patient treatment.

Sample requirements

  • HLA typing: 5ml EDTA

Find out more about sample packaging, labelling and transport.