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Testing for FNAIT, PTP and TRALI investigation

Published on 03 September 2019

Our lab carries out human platelet antigen (HPA) and human neutrophil antigen (HNA) genotyping and antibody screening.

Fetal/neonatal alloimmune thrombocytopenia (FNAIT)

HPA antibody and genotype testing is used in suspected cases of FNAIT.

Our form for initial request of FNAIT investigation should be completed with SNBTS clinical staff.

Download our FNAIT initial request form (Word doc, 255KB).

Post-transfusion purpura (PTP)

HPA antibody and genotype testing is used in suspected cases of PTP.

Transfusion-related acute lung injury (TRALI)

Human leucocyte antigen (HLA) and human neutrophil antigen (HNA) antibody screening are used in suspected cases of TRALI.

Our form for TRALI investigation should be completed with SNBTS clinical staff.

Download our TRALI investigation form (PDF, 389KB).

You should note that all samples for HNA testing and confirmatory HPA antibody testing by monoclonal antibody-specific immobilization of platelet antigen (MAIPA) will be sent to the NHS Blood and Transplant (NHSBT) Platelet and Granulocyte Reference Lab in Filton, Bristol.

Sample requirements

All samples must be sent with the relevant request form and must be less than 48 hours old when received by the lab.

FNAIT              

  • Mother: 2 x 7ml and 1 x 5ml EDTA samples
  • Father: 5ml EDTA sample
  • Baby: 1ml EDTA sample

PTP

  • Patient: 2 x 7ml clotted and 1 x 5ml EDTA samples

TRALI              

  • Patient: 2 x 5ml EDTA samples

Find out more about our sample packaging, labelling and transport requirements.