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IRIC safety alert

MHRA Device Safety Information – MDSI2303

Published on 15 February 2023

From: Health Facilities Scotland

MDSI2303 - Zimmer Biomet NexGen Knee replacement: affected patients should be offered additional follow up.



The National Joint Registry (NJR) has identified that both the NexGen® Stemmed Option Tibial Components, when paired with either the Legacy® Posterior Stabilized (LPS) Flex Option Femoral or the LPS Flex Gender Solutions Femoral (GSF) Option Femoral, had a higher overall revision rate and a higher revision rate for aseptic tibial loosening compared to the average revision rate of all other total knee replacements in the UK NJR.